My Sweet Audrina is a 1982 novel by V. C. Andrews. It was the only standalone novel published during Andrews' lifetime and was a number one best-selling novel in North America. The story takes place in the Southeastern United States during the 1960s—1970s. The story features diverse real-world subjects such as brittle bone disease, rape, posttraumatic stress disorder, diabetes, and autism in the haunting setting of a Victorian era mansion near the fictitious River Lyle.