Route 165 is a 22 km (14 mi)-long north-south secondary highway in the western New Brunswick, Canada. The route's northern terminus is in downtown Woodstock, New Brunswick at Route 103, where the road is known as Main Street. From there, it runs south along the western bank of the Saint John River to the small community of Meductic. From there, the highway stops following the Saint John River and takes a slight southern turn which brings it to its terminus at an intersection with Route 2 (exit 212) and Route 122.