New York State Route 321 (NY 321) is a state highway in Onondaga County, New York, in the United States. The southern terminus of the route is at an intersection with U.S. Route 20 (US 20) in the village of Skaneateles. Its northern terminus is at an intersection with NY 5 in Bennetts Corners, a hamlet within the town of Camillus. NY 321 is predominantly a north–south highway; however, a portion of the route through the towns of Elbridge and Camillus follows an east–west alignment. The portion of NY 321 in Camillus between Forward Road and NY 5 is maintained by Onondaga County as part of County Route 66 (CR 66), a route that continues north of NY 5 to Memphis.