New York State Route 481 (NY 481) is a state highway in Central New York in the United States. The southern terminus of the route is at an interchange with Interstate 81 (I-81) in North Syracuse, where the highway continues southeastward as I-481. Its northern terminus is located at an intersection with NY 104 in Oswego about two blocks from Lake Ontario. In between, NY 481 serves the communities of Clay, Phoenix and Fulton along the Oswego River. NY 481 is one of two state routes in the Syracuse area that serves as an extension of an Interstate Highway; the other is NY 690.