New York State Route 49 (NY 49) is an east–west state highway in central New York in the United States. It runs for just over 64 miles (103 km) from an intersection with NY 3 in the town of Volney (east of Fulton) to an interchange with Interstate 790 (I-790), NY 5, NY 8 and NY 12 in the city of Utica. The route follows a generally northwest–southeast alignment between the two points, passing along the north shore of Oneida Lake and directly serving the city of Rome. As NY 49 heads east, it connects to several highways of regional importance, such as I-81 in the village of Central Square and NY 13 in the town of Vienna. Most of NY 49 is a two-lane surface road; however, the section between Rome and Utica is a freeway known as the Utica–Rome Expressway.