New York State Route 598 (NY 598) is a north–south state highway located within Onondaga County, New York, in the United States. It extends for 2.31 miles (3.72 km) from an intersection with NY 5 in the city of Syracuse to a junction with NY 298 in the adjacent town of Salina. The route intersects Interstate 690 (I-690) near its southern terminus and passes through Syracuse's Eastwood neighborhood near its midpoint, where it meets NY 290.