The Nickels-Sortwell House is a historic house museum at 121 Main Street in Wiscasset, Maine, United States. Built in 1807 by a wealthy ship's captain, the house was designated a National Historic Landmark in 1970 as an exceptionally high-quality example of the Federal style of architecture. After serving as a hotel for much of the 19th century, the house returned to private hands in 1900. It was given to Historic New England in 1958, which gives tours of the house between May and October.