State Route 516 (SR 516) is a two-lane east-west state highway that runs entirely within Tuscarawas County in eastern Ohio. The western terminus of State Route 516 is at State Route 93 in Dundee. Its eastern terminus is at a signalized intersection with State Route 39 in Dover, just one block west of the Interstate 77/U.S. Route 250 freeway. Created in the late 1930s, State Route 516 serves primarily rural portions of northwestern Tuscarawas County including Winfield, Ohio.