Rib-X Pharmaceuticals, founded in 2000, is an American privately held biopharmaceutical firm that focuses on the design and development of novel broad-spectrum antibiotics for the treatment of antibiotic-resistant infections in hospital and community settings. The company is located in New Haven, Connecticut. Rib-X seeks to exploit expertise in the structural biology (particularly ribosomal structure) and molecular modeling to design new antibiotics. With this technology they hope to design drug candidates with increased target affinity that overcome bacterial resistance, broadened antibacterial spectrum, and increased efficacy and safety.