SKF-83,959
SKF-83,959 is a synthetic benzazepine derivative used in scientific research which acts as an agonist at the D1-D2 dopamine receptor. It behaves as a full agonist at the D1 protomer and a high-affinity partial agonist at the D2 protomer. It was further shown to act as an allosteric modulator of the sigma-1 receptor. SKF-83,959 is a racemate that consists of the R-(+)- and S-(−)-enantiomers MCL 202 and MCL 201, respectively. SKF-83,959 inhibits sodium channels as well as delayed rectifier potassium channels.
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SKF-83,959
SKF-83,959 is a synthetic benzazepine derivative used in scientific research which acts as an agonist at the D1-D2 dopamine receptor. It behaves as a full agonist at the D1 protomer and a high-affinity partial agonist at the D2 protomer. It was further shown to act as an allosteric modulator of the sigma-1 receptor. SKF-83,959 is a racemate that consists of the R-(+)- and S-(−)-enantiomers MCL 202 and MCL 201, respectively. SKF-83,959 inhibits sodium channels as well as delayed rectifier potassium channels.
has abstract
SKF-83,959 is a synthetic benz ...... rectifier potassium channels.
@en
IUPAC name
6-chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine
@en
PubChem
thumbnail
Wikipage page ID
23,684,873
Wikipage revision ID
723,576,660
ChEMBL
ChemSpiderID
10,131,933
molecular weight
smiles
Br.Clc1c3cCCNC
StdInChIKey
FHYWNBUFNGHNCP-UHFFFAOYSA-N
verifiedrevid
464,385,404
Watchedfields
subject
comment
SKF-83,959 is a synthetic benz ...... rectifier potassium channels.
@en
label
SKF-83,959
@en