San Francisquito Creek (Spanish for "Little San Francisco" - the "little" referring to size of the creek, not the saint) is a creek that flows into southwest San Francisco Bay in California, United States of America. Historically it was called the Arroyo de San Francisco by Juan Bautista de Anza in 1776. San Francisquito Creek courses through the towns of Portola Valley and Woodside, as well as the cities of Menlo Park, Palo Alto, and East Palo Alto. The creek and its Los Trancos Creek tributary define the boundary between San Mateo and Santa Clara Counties.