Serpentine is a town in north west Victoria, Australia. Located on the Loddon Valley Highway, the town is 201 kilometres north west of the state capital, Melbourne and 51 kilometres north west of the regional centre, Bendigo. Serpentine is in the Shire of Loddon local government area and, including the surrounding state suburb, had a population of 307 at the 2011 census. The town is named for Serpentine Creek, a tributary of the Loddon River. The creek in turn was named for explorer Thomas Mitchell's description of the river red gum trees lining the rivers and creeks of the area.