Shedsu-nefertum was a High Priest of Ptah at the end of the 21st dynasty and beginning of the 22nd dynasty. Shedsunefertem was the son of the High Priest Ankhefensekhmet and the lady Tapeshenese, who was First Chief of the Harem of Ptah and Prophetess of Mut. Shedsu-nefertum had two wives. One of his wives was named Mehtenweskhet, who was probably a daughter of Nimlot A and Tentsepeh A. She was thus a sister of Shoshenq I. The other wife was named Tentsepeh B. She may have been a daughter of Psusennes II.