The Siege of 's-Hertogenbosch of 1601 (Sitio de Bolduque de 1601 in Spanish) was an unsuccessful Dutch attempt led by Prince Maurice of Nassau and William Louis of Nassau-Dillenburg to capture the city of 's-Hertogenbosch, North Brabant, Spanish Netherlands, garrisoned by about 1,500–2,000 Spanish soldiers (2 infantry companies and 2 cavalry companies) led by Governor Anthonie Schetz, Baron of Grobbendonck, between 1 and 27 November 1601, during the Eighty Years' War and the Anglo-Spanish War (1585–1604), in the context of the long and bloodiest Siege of Ostend.