USS Colhoun (DD-85/APD-2) was a Wickes-class destroyer in the United States Navy during World War I and later redesignated APD-2 in World War II. She was the first Navy ship named for Edmund Colhoun. Launched in 1918, she remained on convoy duty for the final few months of World War I, and she then operated out of the Atlantic for several years until being decommissioned in 1922. Returning to service in 1940 as a high-speed troop transport, Colhoun was dispatched to support the Guadalcanal campaign early in World War II. While unloading supplies to the island on 31 August 1942, she was attacked by aircraft of the Empire of Japan, and sunk with the loss of 50 men.