USS Truxtun (DD-229) was a Clemson-class destroyer in the United States Navy during World War II. She was the third ship named for Thomas Truxtun. Truxtun was laid down on 3 December 1919 and launched on 28 September 1920 from William Cramp & Sons, sponsored by Miss Isabelle Truxtun Brumby, and commissioned at the Philadelphia Navy Yard on 16 February 1921, Lieutenant Commander Melville S. Brown in command.