Wasena is a Roanoke, Virginia (United States) neighborhood located in south, central Roanoke bisected by U.S. Route 221 (Main Street), immediately to the south of the Roanoke River. It borders the neighborhoods of Raleigh Court on the west, Old Southwest on the north and east and Mountain View via the Wasena Bridge across the Roanoke River on the north, and Franklin-Colonial on the south. As of the 2000 U.S. Census, Wasena has a population of 1,633 residents.