At its south end, Weston Road begins at Keele Street and St. Clair Avenue (Keele Street is cut off north of this location). Until May 2006, it began approximately 50 metres north of St. Clair, until a by-law was passed to change this.Weston Rd. then travels in a northwest direction to Highway 401, passing through Mount Dennis at Eglinton Avenue, and Weston north of Lawrence Avenue. North of the 401, it is a north-south road to Steeles Avenue and continues into in York Region.