1,3-Beta-glucan synthase
1,3-Beta-glucan synthase is a glucosyltransferase enzyme involved in the generation of beta-glucan in fungi. It serves as a pharmacological target for antifungal drugs such as caspofungin, anidulafungin, and micafungin, deemed 1,3-Beta-glucan synthase inhibitors. Under the CAZy classification system, fungi and plant members fall in the glycosyltransferase 48 family (GT48). Some members of the (Pfam PF13632), such as the curdlan synthase CrdS (Q7D3X8), also has a similar activity. UDP-glucose + {(1,3)-beta-D-glucosyl}(N) = UDP + {(1,3)-beta-D-glucosyl}(N+1).
1,3-b-glucan synthase1,3-b glucan synthase1,3-beta-glucan synthase1,3-β glucan synthaseAntifungalAspergillus nidulansBeta-glucanCaspofunginCell wallEC 2.4.1.34EchinocandinEchinocandin BGS-IIGlycosyltransferaseList of EC numbers (EC 2)Septum (cell biology)UDP-glucose:(1-3)-beta-D-glucan 3-beta-D-glucosyltransferaseΒ-1,3-glucan synthase
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1,3-Beta-glucan synthase
1,3-Beta-glucan synthase is a glucosyltransferase enzyme involved in the generation of beta-glucan in fungi. It serves as a pharmacological target for antifungal drugs such as caspofungin, anidulafungin, and micafungin, deemed 1,3-Beta-glucan synthase inhibitors. Under the CAZy classification system, fungi and plant members fall in the glycosyltransferase 48 family (GT48). Some members of the (Pfam PF13632), such as the curdlan synthase CrdS (Q7D3X8), also has a similar activity. UDP-glucose + {(1,3)-beta-D-glucosyl}(N) = UDP + {(1,3)-beta-D-glucosyl}(N+1).
has abstract
1,3-Beta-glucan synthase is a ...... {(1,3)-beta-D-glucosyl}(N+1).
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La 1,3-beta-glucano sintasi è ...... ⇄ UDP + (1,3-β-D-glucosil)n+1
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EC number
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12,931,666
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991,927,932
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CAS number
CAZy
GT48
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EC number
InterPro
IPR003440
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IUBMB EC number
name
Glycosyl transferase, family 48
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Pfam
PF02364
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Pfam clan
CL0111
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symbol
Glucan_synthase
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1,3-Beta-glucan synthase is a ...... {(1,3)-beta-D-glucosyl}(N+1).
@en
La 1,3-beta-glucano sintasi è ...... ⇄ UDP + (1,3-β-D-glucosil)n+1
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label
1,3-Beta-glucan synthase
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1,3-beta-glucano sintasi
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name
1,3-Beta-glucan synthase
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