The 10th South Carolina Infantry Regiment was a Confederate volunteer infantry unit from the state of South Carolina during the American Civil War. It fought with the Army of Tennessee in the Western Theater for the duration of the war. Originally organized to serve for twelve months it was reorganized for the war in 1862. Sent east to fight in the Carolinas Campaign in 1865 it was consolidated with the and formed . The unit surrendered with General Joseph E. Johnston and the Army of Tennessee at Bennett Place on April 26, 1865. Out of 2189 men listed on the regimental muster rolls throughout the conflict only 55 enlisted men remained to be paroled.