The 1926 Targa Florio was a Grand Prix motor race held on the 108km Medio Circuito Madonie in Sicily, Italy on 25 April 1926. There were two separate races held simultaneously, one for up to 1100cc Cyclecars held over 3 laps for a total distance of 324km, and the main race for Formula Libre cars over 5 laps for a total distance of 540km. The longer race also featured the 1926 Coppa Florio which was open only to factory entered cars. The Cyclecar race was won by Baconin Borzacchini driving a Salmson, while the longer race and Coppa Florio were won by Meo Costantini in his factory entered Bugatti.