The 1943 Ontario general election was held on August 4, 1943, to elect the 90 Members of the 21st Legislative Assembly of Ontario (Members of Provincial Parliament, or "MPPs") of the Province of Ontario. The Ontario Progressive Conservative Party, led by George Drew, defeated the Ontario Liberal Party government. The Liberal government had disintegrated over the previous two years because of a conflict between Mitchell Hepburn, the Ontario caucus and the federal Liberal Party of Canada.