The 1946 Missouri Tigers football team was an American football team that represented the University of Missouri in the Big Six Conference (Big 6) during the 1946 college football season. The team compiled a 5–4–1 record (3–2 against Big 6 opponents), finished in a tie for third place in the Big 6, and was outscored by all opponents by a combined total of 166 to 158. The team played its home games at Memorial Stadium in Columbia, Missouri. The team's leading scorers were Howard Bonnett and Loyd Brinkman, each with 30 points.