The 43° Targa Florio was a motor race for sportscars held on 24 May 1959 on the Circuito Piccolo delle Madonie, Sicily, Italy. It was the second round of the 1959 F.I.A. World Sports Car Championship and the 43rd running of the Targa Florio. Early that year, the event founder, Vincenzo Florio died and his nephew Vincent Paladion promised to keep alive Florio's Targa. “The Targa must continue... Promise me!..” The race was won by Edgar Barth and Wolfgang Seidel driving a Porsche 718 RSK entered by Porsche KG.