20-Hydroxyeicosatetraenoic acid
20-Hydroxyeicosatetraenoic acid, also known as 20-HETE or 20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid, is an eicosanoid metabolite of arachidonic acid that has a wide range of effects on the vascular system including the regulation of vascular tone, blood flow to specific organs, sodium and fluid transport in the kidney, and vascular pathway remodeling. These vascular and kidney effects of 20-HETE have been shown to be responsible for regulating blood pressure and blood flow to specific organs in rodents; genetic and preclinical studies suggest that 20-HETE may similarly regulate blood pressure and contribute to the development of stroke and heart attacks. Additionally the loss of its production appears to be one cause of the human neurological disease, Hereditary spastic paraplegia. Pr
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20-HETE20-hydroxyarachidonic acid20-hydroxyeicosatetraenoic acidC20H32O3CYP1A1CYP1A2CYP2C9CYP2E1CYP2U11,2-dimethoxyethaanCYP4A11CYP4F11CYP4F12CYP4F2CYP4F22CYP4F3CYP4F8CYP4Z1Cytochrome P450Cytochrome P450 omega hydroxylaseEicosanoidEpoxydocosapentaenoic acidEpoxyeicosatetraenoic acidEpoxyeicosatrienoic acidEpoxygenaseGene polymorphismHETEHydroxyeicosatetraenoic acidMonooxygenaseOmega hydroxy acidOmega oxidationTRPV1Thromboxane receptor
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20-Hydroxyeicosatetraenoic acid
20-Hydroxyeicosatetraenoic acid, also known as 20-HETE or 20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid, is an eicosanoid metabolite of arachidonic acid that has a wide range of effects on the vascular system including the regulation of vascular tone, blood flow to specific organs, sodium and fluid transport in the kidney, and vascular pathway remodeling. These vascular and kidney effects of 20-HETE have been shown to be responsible for regulating blood pressure and blood flow to specific organs in rodents; genetic and preclinical studies suggest that 20-HETE may similarly regulate blood pressure and contribute to the development of stroke and heart attacks. Additionally the loss of its production appears to be one cause of the human neurological disease, Hereditary spastic paraplegia. Pr
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20-Hydroxyeicosatetraenoic aci ...... ticularly those of the breast.
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alternative name
20-HETE, 20-Hydroxy-5,8,11,14-eicosatetraenoic, 20-Hydroxyeicosatetraenoic acid
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IUPAC name
(5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoic acid
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47,836,404
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1,018,382,865
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20-Hydroxyeicosatetraenoic aci ...... editary spastic paraplegia. Pr
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label
20-Hydroxyeicosatetraenoic acid
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