2006 US Open – Mixed Doubles

Daniela Hantuchová and Mahesh Bhupathi were the defending champions, but neither participated in the Mixed Doubles tournament. Martina Navratilova and Bob Bryan won the title, defeating Květa Peschke and Martin Damm in the final 6–2, 6–3. It would be Navratilova's 59th and final Grand Slam title, 32 years after her first.

2006 US Open – Mixed Doubles

Daniela Hantuchová and Mahesh Bhupathi were the defending champions, but neither participated in the Mixed Doubles tournament. Martina Navratilova and Bob Bryan won the title, defeating Květa Peschke and Martin Damm in the final 6–2, 6–3. It would be Navratilova's 59th and final Grand Slam title, 32 years after her first.