The 2010 1000 Guineas Stakes was a horse race held at Newmarket Racecourse on Sunday 2 May 2010. It was the 197th running of the 1000 Guineas. The winner was Khalid Abdulla's Special Duty, a three-year-old chestnut filly trained at Chantilly in France by Criquette Head-Maarek and ridden by Stéphane Pasquier. The Henry Cecil-trained Jacqueline Quest finished first by a nose but the placings of the first two finisher were reversed after a stewards' inquiry. Special Duty's victory was the first in the race for Pasquier and the fourth in the race for Head-Maarek after Ma Biche (1982), Ravinella (1988) and Hatoof (1992). Khalid Abdulla had previously won the race with Wince in 1999.