5-Methoxy-7,N,N-trimethyltryptamine
5-Methoxy-7,N,N-trimethyltryptamine (5-MeO-7,N,N-TMT, 5-MeO-7-TMT), is a tryptamine derivative which acts as an agonist at the 5-HT2 serotonin receptors. In animal tests, both 7,N,N-TMT and 5-MeO-7,N,N-TMT produced behavioural responses similar to those of psychedelic drugs such as DMT and 5-MeO-DMT, but compounds with larger 7-position substituents such as 7-ethyl-DMT and 7-bromo-DMT did not produce psychedelic-appropriate responding despite high 5-HT2 receptor binding affinity, suggesting these may be antagonists or weak partial agonists for the 5-HT2 receptors. The related compound 7-MeO-MiPT (cf. 5-MeO-MiPT) was also found to be inactive, suggesting that the 7-position has poor tolerance for bulky groups at this position, at least if agonist activity is desired.
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5-Methoxy-7,N,N-trimethyltryptamine
5-Methoxy-7,N,N-trimethyltryptamine (5-MeO-7,N,N-TMT, 5-MeO-7-TMT), is a tryptamine derivative which acts as an agonist at the 5-HT2 serotonin receptors. In animal tests, both 7,N,N-TMT and 5-MeO-7,N,N-TMT produced behavioural responses similar to those of psychedelic drugs such as DMT and 5-MeO-DMT, but compounds with larger 7-position substituents such as 7-ethyl-DMT and 7-bromo-DMT did not produce psychedelic-appropriate responding despite high 5-HT2 receptor binding affinity, suggesting these may be antagonists or weak partial agonists for the 5-HT2 receptors. The related compound 7-MeO-MiPT (cf. 5-MeO-MiPT) was also found to be inactive, suggesting that the 7-position has poor tolerance for bulky groups at this position, at least if agonist activity is desired.
has abstract
5-Methoxy-7,N,N-trimethyltrypt ...... f agonist activity is desired.
@en
5-метокси-7,N,N-триметилтрипта ...... и агонистами 5-HT2 рецепторов.
@ru
CAS number
61018-77-7
74798-76-8 oxalate salt
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PubChem
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27,484,376
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992,644,769
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CAS supplemental
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ChEMBL
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10,578,304
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IUPAC name
PubChem
12,338,919
SMILES
CC1=CC2=CC=C1
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StdInChIKey
YGAOMGVUIWNFMD-UHFFFAOYSA-N
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changed
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verifiedrevid
477,225,204
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5-Methoxy-7,N,N-trimethyltrypt ...... f agonist activity is desired.
@en
5-метокси-7,N,N-триметилтрипта ...... и агонистами 5-HT2 рецепторов.
@ru
label
5-Methoxy-7,N,N-trimethyltryptamine
@en
5-метокси-7,N,N-триметилтриптамин
@ru
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5-Methoxy-7,N,N-trimethyltryptamine
@en