"A Shot of Rhythm and Blues" is a song written by Terry Thompson and first recorded by US soul singer Arthur Alexander. It was originally released in the United States in 1961 and in the United Kingdom the following year, as the B-side of "You Better Move On". As well as having Rhythm and Blues in the title, the song is itself an R&B number. Featuring only blues chords, it begins as an apparent 12-bar blues, but then diverges from that standard structure into a more distinctive composition.