Activin and inhibin
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Identified in 1986, activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Conversely, inhibin downregulates FSH synthesis and inhibits FSH secretion. The existence of inhibin was hypothesized as early as 1916; however, it was not demonstrated to exist until Neena Schwartz and Cornelia Channing's work in the mid 1970s, after which both proteins were molecularly characterized ten years later.
Activin and inhibinACVR1ACVR1BACVR2BAbortion–breast cancer hypothesisAcceleron PharmaActaActivinActivin AActivin ABActivin BActivin receptorActivin type 1 receptorsActivinsAdjudinAnti-Müllerian hormoneArtificial ovaryAzoospermiaBiochemical cascadeC19orf18CFC domainCell signalingCornelia ChanningCorpus luteumCounterregulatory hormoneDorsal lipDown syndromeEctoderm specificationEctopic pregnancyEmbryokineEndoglinEpiblast-derived stem cellEstrogen insensitivity syndromeFOXL2Female infertilityFibroblast growth factor and mesoderm formationFibrodysplasia ossificans progressivaFollicle-stimulating hormoneFollicle-stimulating hormone insensitivityFollicular phase
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Activin and inhibin
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Identified in 1986, activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Conversely, inhibin downregulates FSH synthesis and inhibits FSH secretion. The existence of inhibin was hypothesized as early as 1916; however, it was not demonstrated to exist until Neena Schwartz and Cornelia Channing's work in the mid 1970s, after which both proteins were molecularly characterized ten years later.
has abstract
Activin and inhibin are two cl ...... the TGF-β protein superfamily.
@en
La activina e inhibina son dos ...... erfamilia de proteínas TGF-β.
@es
الأكتيفين والإنهيبين هما مركبا ...... امل النمو المحول بيتا الفائقة.
@ar
激活素(英語:Activin,亦成为激活蛋白或活化素)与抑制素(英語:inhibin)是一种用于抑制卵泡刺激素分泌与组合的 。参与在月经周期的调节中。
@zh
액티빈(영어: activin)과 인히빈(영어: inhi ...... 두 단백질은 10 년 후 분자적으로 특성이 분석되었다.
@ko
arm
band
chromosome
EntrezGene
HGNCid
locus supplementary data
OMIM id
RefSeq
Symbol
UniProt
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22,470,207
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1,024,536,431
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label
Activin and inhibin
@en
Activina e inhibina
@es
الأكتيفين والإنهيبين
@ar
激活素与抑制素
@zh
액티빈과 인히빈
@ko
name
@en
inhibin, alpha
@en
inhibin, beta A
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inhibin, beta B
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inhibin, beta C
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inhibin, beta E
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AltSymbols
activin A
@en
activin B
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activin C
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activin E
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Arm
p
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q
@en
band
caption
The Activin dimer, from 2ARV.pdb
@en
Chromosome
EntrezGene
HGNCid
LocusSupplementaryData
cen-q13
@en
OMIM
RefSeq
NM_002191
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NM_002192
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NM_002193
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NM_005538
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NM_031479
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UniProt
P05111
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P08476
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P09529
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P55103
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P58166
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comment
Activin and inhibin are two cl ...... characterized ten years later.
@en
La activina e inhibina son dos ...... e inhibe la secreción de FSH.
@es
الأكتيفين والإنهيبين هما مركبا ...... ام الجروح ووظيفة الغدد الصماء.
@ar
激活素(英語:Activin,亦成为激活蛋白或活化素)与抑制素(英語:inhibin)是一种用于抑制卵泡刺激素分泌与组合的 。参与在月经周期的调节中。
@zh
액티빈(영어: activin)과 인히빈(영어: inhi ...... 두 단백질은 10 년 후 분자적으로 특성이 분석되었다.
@ko