Aglossia (aglossia congenita) is a congenital defect resulting in a partial development or complete absence of a tongue. Aglossia is commonly associated with craniofacial and limb defects and is thought to belong to a family of (OLHS). It is believed to be caused by heat-induced vascular disruption near the fourth week of embryonic development. The first known case was reported in the early 18th century by a member of the prominent De Jussieu family in France and cases to this day remain rare.