Ai-Khanoum (Aï Khānum, also Ay Khanum, lit. “Lady Moon” in Uzbek), possibly the historical Alexandria on the Oxus (Greek: Ἀλεξάνδρεια ἡ ἐπὶ τοῦ Ώξου), possibly later named Eucratidia, Εὐκρατίδεια) was one of the primary cities of the Greco-Bactrian Kingdom from circa 280 BCE, and of the Indo-Greek kings when they ruled both in Bactria and northwestern India, from the time of Demetrius I (200-190 BCE) to the time of Eucratides (170–145 BCE). Previous scholars have argued that Ai Khanoum was founded in the late 4th century BC, following the conquests of Alexander the Great. Recent analysis now strongly suggests that the city was founded c. 280 BC by the Seleucid emperor Antiochus I Soter. The city is located in Takhar Province, northern Afghanistan, at the confluence of the Panj River and th