Amino acid activation

Amino acid activation (also known as aminoacylation or tRNA charging) refers to the attachment of an amino acid to its Transfer RNA (tRNA). * Aminoacyl transferase binds Adenosine triphosphate (ATP) to amino acid, PP is released. * Aminoacyl TRNA synthetase binds AMP-amino acid to tRNA. The AMP is used in this step. 1. * aa + ATP ⟶ aa-AMP + PP, (pyrophosphate) 2. * aa-AMP + tRNA ⟶ aa-tRNA + AMP The error frequency of the amino acid activation reaction is approximately 1 in 10,000 despite the small structural differences between some of the amino acids.

Amino acid activation

Amino acid activation (also known as aminoacylation or tRNA charging) refers to the attachment of an amino acid to its Transfer RNA (tRNA). * Aminoacyl transferase binds Adenosine triphosphate (ATP) to amino acid, PP is released. * Aminoacyl TRNA synthetase binds AMP-amino acid to tRNA. The AMP is used in this step. 1. * aa + ATP ⟶ aa-AMP + PP, (pyrophosphate) 2. * aa-AMP + tRNA ⟶ aa-tRNA + AMP The error frequency of the amino acid activation reaction is approximately 1 in 10,000 despite the small structural differences between some of the amino acids.