The Amos Block is a Romanesque Revival building located on the southwest corner of Clinton Square in Downtown Syracuse, New York. The building's developer and namesake, Jacob Amos, served as mayor of Syracuse from 1892 to 1896. Originally, the Erie Canal ran directly behind the Amos Block, and goods were loaded and unloaded from the building's upper levels onto the Canal, while the first floor on the West Water St side contained a retail grocer. The building was added to the National Register of Historic Places in 1978.