Andromeda XXI (And 21, And XXI) is a moderately bright dwarf spheroidal galaxy about 859 ± 51 kiloparsecs (2.80 ± 0.17 Mly) away from the Sun in the constellation Andromeda. It is the fourth largest Local Group dwarf spheroidal galaxy. This large satellite of the Andromeda Galaxy (M31) has a half-light radius of nearly 1 kpc. The discovery arose from the first year data of a of the M31/M33 subgroupings of the Local Group by the Pan-Andromeda Archaeological Survey (PAndAS). This survey was conducted with the Megaprime/MegaCam wide-field camera mounted on the Canada-France-Hawaii Telescope.