Anna Tuthill Harrison (née Symmes; July 25, 1775 – February 25, 1864), wife of President William Henry Harrison and grandmother of President Benjamin Harrison, was nominally First Lady of the United States during her husband's one-month term in 1841, but she never entered the White House. At the age of 65 years during her husband's presidential term, she was the oldest woman ever to become First Lady (a title held until Jill Biden became First Lady in 2021), as well as having the distinction of holding the title for the shortest length of time, and the first person to be widowed while holding the title. She was the last First Lady to have been born in British America.