Antonio Ponce de Santa Cruz (1561–1632) was the court physician in the royal courts of Philip III and Philip IV. Antonio was also a university professor at the University of Valladolid and a clergyman. He was interested in lycanthropy, free will, and the role of love in causing madness. He published his father Alonso's book Dignotio et cura affectuum melancholicorum (Diagnóstico y tratamiento de las afecciones de los melancólicos) about the diagnosis and treatment of melancholy posthumously in 1622.He published the first Spanish treatise on epilepsy in 1631, Praelections Valliosoletanae.