Aspartoacylase
Aspartoacylase is a hydrolase enzyme (EC 3.5.1.15, aminoacylase II, N-acetylaspartate amidohydrolase, acetyl-aspartic deaminase, acylase II, ASPA) that in humans is encoded by the ASPA gene. ASPA is responsible for catalyzing the deacylation of N-acetyl-l-aspartate (N-acetylaspartate) into aspartate and acetate. It is a zinc-dependent hydrolase that promotes the deprotonation of water to use as a nucleophile in a mechanism analogous to many other zinc-dependent hydrolases. It is most commonly found in the brain, where it controls the levels of N-actetyl-l-aspartate. Mutations that result in loss of aspartoacylase activity are associated with Canavan disease, a rare autosomal recessive neurodegenerative disorder.
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ASPAASPA (gene)Acetyl-aspartic deaminaseAcylase IIAminoacylaseAminoacylase IICanavan diseaseChromosome 17Dentate nucleusEC 3.5.1.15Human genomeLeukodystrophyList of EC numbers (EC 3)List of OMIM disorder codesList of genetic disordersList of human protein-coding genes 1Medical genetics of JewsN-Acetylaspartic acidN-acetylaspartate amidohydrolaseN-acyl-L-aspartate amidohydrolaseSpongy degeneration of the central nervous system
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Aspartoacylase
Aspartoacylase is a hydrolase enzyme (EC 3.5.1.15, aminoacylase II, N-acetylaspartate amidohydrolase, acetyl-aspartic deaminase, acylase II, ASPA) that in humans is encoded by the ASPA gene. ASPA is responsible for catalyzing the deacylation of N-acetyl-l-aspartate (N-acetylaspartate) into aspartate and acetate. It is a zinc-dependent hydrolase that promotes the deprotonation of water to use as a nucleophile in a mechanism analogous to many other zinc-dependent hydrolases. It is most commonly found in the brain, where it controls the levels of N-actetyl-l-aspartate. Mutations that result in loss of aspartoacylase activity are associated with Canavan disease, a rare autosomal recessive neurodegenerative disorder.
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Aspartoacylase is a hydrolase ...... ve neurodegenerative disorder.
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1,008,939,145
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Structure of aspartoacylase dimer. Generated from 2I3C.
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Aspartoacylase
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Aspartoacylase is a hydrolase ...... ve neurodegenerative disorder.
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Aspartoacylase
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