Autoimmune lymphoproliferative syndrome
Autoimmune lymphoproliferative syndrome (ALPS), is a form of lymphoproliferative disorder (LPDs). It affects lymphocyte apoptosis. It is a rare genetic disorder of abnormal lymphocyte survival caused by defective Fas mediated apoptosis. Normally, after infectious insult, the immune system down-regulates by increasing Fas expression on activated B and T lymphocytes and Fas-ligand on activated T lymphocytes. Fas and Fas-ligand interact to trigger the caspase cascade, leading to cell apoptosis. Patients with ALPS have a defect in this apoptotic pathway, leading to chronic non-malignant lymphoproliferation, autoimmune disease, and secondary cancers.
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ALPSAlps (disambiguation)Autoimmune lymphoproliferative syndrome (ALPS)Cancer syndromeCaspase-8 deficiencyCaspase 8Castleman diseaseEosinophiliaEpstein–Barr virus-associated lymphoproliferative diseasesEvans syndromeFas ligandHemophagocytic lymphohistiocytosisImmune disorderIndex of molecular biology articlesList of autoimmune diseasesList of medical abbreviations: AList of primary immunodeficienciesList of syndromesLymphoproliferative disordersMichael J. LenardoRAS-associated autoimmune leukoproliferative disorderRASopathySplenomegalyStephen Straus
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Autoimmune lymphoproliferative syndrome
Autoimmune lymphoproliferative syndrome (ALPS), is a form of lymphoproliferative disorder (LPDs). It affects lymphocyte apoptosis. It is a rare genetic disorder of abnormal lymphocyte survival caused by defective Fas mediated apoptosis. Normally, after infectious insult, the immune system down-regulates by increasing Fas expression on activated B and T lymphocytes and Fas-ligand on activated T lymphocytes. Fas and Fas-ligand interact to trigger the caspase cascade, leading to cell apoptosis. Patients with ALPS have a defect in this apoptotic pathway, leading to chronic non-malignant lymphoproliferation, autoimmune disease, and secondary cancers.
has abstract
Auto-immuun lymfoproliferatief ...... poptotische eiwit BIM een rol.
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Autoimmune lymphoproliferative ...... isease, and secondary cancers.
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Décrit en 1967, le syndrome ly ...... olifératifs de cause inconnue.
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El Síndrome Linfoproliferativo ...... del grupo de las rasopatías.
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Sindrom limfoproliferatif auto ...... hingga pertengahan tahun 1990.
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مرض التكاثر الليمفاوي (بالإنجل ...... اوية (بالإنجليزية: Lymphoma).
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997,433,962
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Autoimmune lymphoproliferative syndrome
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OMIM
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synonyms
Canale-Smith syndrome,
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Auto-immuun lymfoproliferatief ...... PS behoort tot de weesziekten.
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Autoimmune lymphoproliferative ...... isease, and secondary cancers.
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Décrit en 1967, le syndrome ly ...... lifératif avec auto-immunité :
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El Síndrome Linfoproliferativo ...... del grupo de las rasopatías.
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Sindrom limfoproliferatif auto ...... ditandai dengan simtoma khas:
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مرض التكاثر الليمفاوي (بالإنجل ...... اوية (بالإنجليزية: Lymphoma).
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label
Auto-immuun lymfoproliferatief syndroom
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Autoimmune lymphoproliferative syndrome
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Sindrom limfoproliferatif autoimun
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Syndrome lymphoprolifératif avec auto-immunité
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Síndrome linfoproliferativo autoinmune
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مرض التكاثر الليمفاوي
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Autoimmune lymphoproliferative syndrome
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