Balthasar of Mecklenburg (1451 – 16 March 1507) was a Duke of Mecklenburg and Coadjutor of the Diocese of Hildesheim between 1471 and 1474 and the Diocese of Schwerin between 1474 and 1479. Balthasar was the youngest son of Henry IV, Duke of Mecklenburg and Dorothea of Brandenburg, the daughter of the Margrave Frederick I of Brandenburg. When he came of age, Balthasar chose an ecclesiastical career. He was coadjutor of the Diocese of Hildesheim in the years 1471-1474 and then in the Diocese of Schwerin from 1474 to 1479. He probably was not satisfied with ecclesiastical life and returned to lay status in 1479. After mediation by his mother, an agreement was reached on 13 January 1480 between him and his older brothers to divide the duchy. His brother Albert VI received the larger part of t