The Blockade of Porto Bello was a failed British naval action against the Spanish port of Porto Bello in present-day Panama between 1726 and 1727 as part of the Anglo-Spanish War. The British were attempting to blockade the port to stop the Spanish treasure fleet leaving for Spain with its valuable cargo. However tropical disease took its toll of the seamen to the extent that the British had to leave to re-crew, during which time the Spanish were able to re-commence shipping operations.