Blyde River Canyon Nature Reserve (or Motlatse Canyon Provincial Nature Reserve) is situated in the Drakensberg escarpment region of eastern Mpumalanga, South Africa. The reserve protects the Blyde River Canyon, including sections of the Ohrigstad and Blyde Rivers and the geological formations around Bourke's Luck Potholes, where the Treur River tumbles into the Blyde below. Southwards of the canyon, the reserve follows the escarpment, to include the Devil's and God's Window, the latter a popular viewpoint to the lowveld at the reserve's southern extremity.