Calanolide A
Calanolide A is an experimental non-nucleoside reverse transcriptase inhibitor (NNRTI). This compound was extracted from the Calophyllum lanigerum, of variety austrocoriaceum, trees in Lundu, Malaysian state of Sarawak in 1992 by United States National Cancer Institute (NCI). Due to rarity of the raw materials and low yield of the active ingredient, total synthesis of the compound was devised in 1996. For the same reason, its sister compound (-)-Calanolide B (also known as Costatolide) have been tauted as replacement. As a result of the discovery of Calanolide A, Sarawak Medichem pharmaceuticals company was established as a joint venture between US-based MediChem Research Inc and Sarawak state government. In 2006, Craun Research, a company established by Sarawak government, acquired Sarawa
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Calanolide A
Calanolide A is an experimental non-nucleoside reverse transcriptase inhibitor (NNRTI). This compound was extracted from the Calophyllum lanigerum, of variety austrocoriaceum, trees in Lundu, Malaysian state of Sarawak in 1992 by United States National Cancer Institute (NCI). Due to rarity of the raw materials and low yield of the active ingredient, total synthesis of the compound was devised in 1996. For the same reason, its sister compound (-)-Calanolide B (also known as Costatolide) have been tauted as replacement. As a result of the discovery of Calanolide A, Sarawak Medichem pharmaceuticals company was established as a joint venture between US-based MediChem Research Inc and Sarawak state government. In 2006, Craun Research, a company established by Sarawak government, acquired Sarawa
has abstract
Calanolide A is an experimenta ...... nical trials for Calanolide A.
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CAS number
142632-32-4
ChEMBL
FDA UNII code
S5A9TQN46W
PubChem
Wikipage page ID
14,562,897
page length (characters) of wiki page
Wikipage revision ID
1,020,536,294
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ATC prefix
none
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CAS number
ChEMBL
ChemSpiderID
IUPAC name
-[10R,11S,12S]-10,11-trans-dihydro-
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metabolism
Hepatic
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protein bound
>97%
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PubChem
SMILES
O=C/4Oc2c\CCCC
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StdInChIKey
NIDRYBLTWYFCFV-FMTVUPSXSA-N
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UNII
S5A9TQN46W
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wikiPageUsesTemplate
hypernym
comment
Calanolide A is an experimenta ...... ak government, acquired Sarawa
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label
Calanolide A
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