The Canoe Brook Historic District encompasses a small but ethnically diverse residential area west of the center of Branford, Connecticut, which exhibits more than 200 years of architectural history. It extends from Cherry Hill Road in the north to Bradley Street in the south, including portions of Main Street, Home Place, and North Harbor Street. It was listed on the National Register of Historic Places in 2002. The district takes its name from Canoe Brook, a waterway now largely built over by North Main Street and other construction.