Château Chasse-Spleen is a winery in the Moulis-en-Médoc appellation of the Bordeaux region of France, just north-west of Margaux. Château Chasse-Spleen was selected as one of six Crus Exceptionnels in the Cru Bourgeois classification of 1932, and through later revisions until the annulment of the classification in 2007. The estate is today widely considered to be of cru classé standard. The name means "to chase away the blues" or "dispels melancholy". A second wine is produced under the label L'Héritage de Chasse-Spleen and another titled l'Oratoire de Chasse-Spleen.