The Roman Catholic Church of the Most Precious Blood is a Roman Catholic church on O'Meara Street in Southwark, London, SE1. The church and its adjoining presbytery, forecourt walls and shrine have been listed Grade II on the National Heritage List for England since 2014. The shrine outside the church to Our Lady of Lourdes (or Our Lady of All Nations) was dedicated in 1957. It is made from Sicilian marble and stands in a niche lined with flint from Norfolk.The church serves the Parish of the Most Precious Blood which was established in 1891 by the Bishop of Southwark, John Baptist Butt upon a bequest of £10,000. The church was designed by the architect Frederick Walters and the combined cost of the construction of the church and adjoining presbytery was £7,000.