Cortactin
Cortactin (from "cortical actin binding protein") is a monomeric protein located in the cytoplasm of cells that can be activated by external stimuli to promote polymerization and rearrangement of the actin cytoskeleton, especially the actin cortex around the cellular periphery. It is present in all cell types. When activated, it will recruit Arp2/3 complex proteins to existing actin microfilaments, facilitating and stabilizing nucleation sites for actin branching. Cortactin is important in promoting lamellipodia formation, invadopodia formation, cell migration, and endocytosis.
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ACTR3ARPC2Actin-binding proteinCDH2CTTNCTTN (gene)FER (gene)FGD1Gelsolin (cellular)Histone deacetylaseKCNA2LamellipodiumList of MeSH codes (D05)List of MeSH codes (D12.644)List of MeSH codes (D12.776)List of MeSH codes (D12.776.157)List of MeSH codes (D12.776.476)List of human protein-coding genes 1P120 (protein)PTPN1PodosomeSHANK2WASL (gene)WIPF11,2-dimethoxyethaan
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Cortactin
Cortactin (from "cortical actin binding protein") is a monomeric protein located in the cytoplasm of cells that can be activated by external stimuli to promote polymerization and rearrangement of the actin cytoskeleton, especially the actin cortex around the cellular periphery. It is present in all cell types. When activated, it will recruit Arp2/3 complex proteins to existing actin microfilaments, facilitating and stabilizing nucleation sites for actin branching. Cortactin is important in promoting lamellipodia formation, invadopodia formation, cell migration, and endocytosis.
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Cortactin (from "cortical acti ...... ll migration, and endocytosis.
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Cortactin (from "cortical acti ...... ll migration, and endocytosis.
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Cortactin
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