Cura Ocllo (died 1539) was an Inca queen, the wife and sister of Manco Inca Yupanqui, puppet and later remnant ruler of the Inca Empire from 1533 until his death in 1544. Her husband was named Sapa Inca in October 1533 after the death of their common brother Túpac Huallpa, who in his turn had succeeded Atahualpa upon his execution by the Spaniards three months earlier. Cura Ocllo likely followed her husband through these events and had a son, Sayri Tupac, with him in 1535, during Manco's time in captivity. Guerrilla war ensued as soon the Spaniards had solved their internal disputes.