D5SICS
d5SICS is an artificial nucleoside containing 6-methylisoquinoline-1-thione-2-yl group instead of a base. It pairs up with dNaM in a hydrophobic interaction. It was not able to be removed by the error-correcting machinery of the E. coli into which it was inserted. The pairing of d5SICS–dNaM is mediated by packing and hydrophobic forces instead of hydrogen bonding, which occurs in natural base pairs. Therefore, in free DNA, rings of d5SICS and dNaM are placed in parallel planes instead of the same plane. The d5SICS-dNaM pairing replaced an older dNaM- pairing.
Wikipage redirect
Link from a Wikipage to another Wikipage
primaryTopic
D5SICS
d5SICS is an artificial nucleoside containing 6-methylisoquinoline-1-thione-2-yl group instead of a base. It pairs up with dNaM in a hydrophobic interaction. It was not able to be removed by the error-correcting machinery of the E. coli into which it was inserted. The pairing of d5SICS–dNaM is mediated by packing and hydrophobic forces instead of hydrogen bonding, which occurs in natural base pairs. Therefore, in free DNA, rings of d5SICS and dNaM are placed in parallel planes instead of the same plane. The d5SICS-dNaM pairing replaced an older dNaM- pairing.
has abstract
d5SICS is an artificial nucleo ...... placed an older dNaM- pairing.
@en
IUPAC name
2-(2-Deoxy-β-(D)-erythro-pentofuranosyl)-6-methylisoquinoline-1(2H)-thione
@en
2-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-methylisoquinoline-1(2H)-thione
@en
Wikipage page ID
47,378,095
page length (characters) of wiki page
Wikipage revision ID
1,023,032,132
Link from a Wikipage to another Wikipage
ImageFile
@en
@en
ImageName
Ball-and-stick model of d5SICS
@en
Haworth projection of d5SICS
@en
IUPACName
name
d5SICS
@en
wikiPageUsesTemplate
subject
hypernym
comment
d5SICS is an artificial nucleo ...... placed an older dNaM- pairing.
@en
label
D5SICS
@en
wasDerivedFrom
isPrimaryTopicOf
name
d5SICS
@en