DS1 or DS-1 may refer to: * BOSS DS-1, a guitar distortion pedal * Digital Signal 1, a T-carrier signaling scheme devised by Bell Labs * Deep Space 1, a mission to 9969 Braille & 19P/Borrelly * DS-1 (drug), a selective GABAA α4β3δ agonist drug * South African Class DS1, a diesel locomotive class * Datsun DS-1, a car by Nissan, see Datsun DS Series * Dark Souls, an action role-playing game * VR Class Ds1, a Finnish railbus class